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KMID : 0620920200520030006
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Experimental & Molecular Medicine
2020 Volume.52 No. 3 p.6 ~ p.6
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Therapeutics targeting the fibrinolytic system
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Lin Haili
Xu Luning
Yu Shujuan
Hong Wanjin
Huang Mingdong
Xu Peng
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Abstract
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The function of the fibrinolytic system was first identified to dissolve fibrin to maintain vascular patency. Connections between the fibrinolytic system and many other physiological and pathological processes have been well established. Dysregulation of the fibrinolytic system is closely associated with multiple pathological conditions, including thrombosis, inflammation, cancer progression, and neuropathies. Thus, molecules in the fibrinolytic system are potent therapeutic and diagnostic targets. This review summarizes the currently used agents targeting this system and the development of novel therapeutic strategies in experimental studies. Future directions for the development of modulators of the fibrinolytic system are also discussed.
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KEYWORD
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Drug development, Proteolysis
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